Comparing the renowned skincare brands Shiseido and SK-II, it’s evident that both offer luxurious serums and essences filled with effective active ingredients. In this article, we will analyze their best-selling anti-aging serums side by side, helping you decide which one suits your skincare routine.

Shiseido Ultimune Power Infusing Concentrate:

Shiseido’s Ultimune Power Infusing Concentrate is our top choice in the Shiseido vs SK-II comparison. This serum claims to enhance skin elasticity, promote radiance, and visibly reduce wrinkles and fine lines. With rave reviews, it is a strong contender for one of the best anti-aging serums available.

The key to its success lies in the combination of skin-nourishing botanical extracts and patented anti-aging technologies. The Ultimune Power Infusing Concentrate features Iris, Reishi Mushroom, Ginkgo Leaf, and Lotus extracts. These ingredients possess anti-stress, anti-oxidant, anti-bacterial, and anti-inflammatory properties, providing comprehensive skincare benefits.

Furthermore, the serum contains ImuGenerationRED, an undisclosed ingredient that reportedly delivers moisturizing collagen, specifically Hydroxyproline, to the skin. Collagen is known for improving skin elasticity and reducing the appearance of wrinkles.

SK-II RNA Power Radical New Age Essence:

The SK-II RNA Power Radical New Age Essence, also known as Skinpower Essence, is a close second choice in the SK-II vs Shiseido comparison. Similar to the Shiseido serum, it claims to improve skin elasticity, enhance radiance, and diminish wrinkles and fine lines.

This essence relies on a unique blend of botanical extracts, namely Calla Lily, Dokudami, and Peony. SK-II refers to this combination as ‘Infinitpower Technology,’ emphasizing their ability to rejuvenate the skin from within and provide a plumping effect.

The key anti-aging ingredient in the Skinpower Essence is PITERA, derived from yeast fermentation. Packed with micro-nutrients like vitamins, minerals, amino acids, and organic acids, PITERA conditions the skin’s natural functions. Notably, its composition closely resembles the skin’s Natural Moisturizing Factors, allowing for fast absorption. The essence also contains Niacinamide, which improves the skin’s barrier function, tone, and firmness.

Clinical trial results:

Shiseido has published clinical trial results demonstrating that approximately 90% of their customers experienced healthier, renewed, and smoother skin after eight weeks of using the Ultimune Power Infusing Concentrate. On the other hand, SK-II has shared only a few testimonials, lacking empirical data to support their claims.

Price comparison:

The most significant difference between the two serums is their price. The SK-II Skinpower Essence is approximately three times more expensive per fluid ounce than Shiseido’s Ultimune Power Infusing Concentrate.

Frequently Asked Questions

Are Shiseido and SK-II suitable for all skin types?

Both Shiseido and SK-II offer skincare products suitable for various skin types. However, it’s always recommended to check the product labels or consult with a dermatologist to ensure compatibility with your specific skin type.

Can I use Shiseido and SK-II products together?

Yes, you can incorporate products from both brands into your skincare routine. However, it’s essential to consider the specific ingredients and potential interactions between different products. It’s best to follow the recommended usage instructions and consult a skincare professional if you have any concerns.

Are Shiseido and SK-II products safe for sensitive skin?

Shiseido and SK-II offer some products formulated specifically for sensitive skin. These products are usually labeled as suitable for sensitive skin or free from potential irritants. Nevertheless, it’s advisable to patch-test new products and monitor your skin’s reaction before applying them to your entire face.

How long does it take to see results with Shiseido and SK-II products?

The timeframe for seeing results may vary depending on the individual and the specific product used. Some products may provide visible improvements in a short period, while others may require more extended usage to achieve desired results. It’s important to follow the recommended application frequency and be patient while allowing the products to work their magic.

Can Shiseido and SK-II products be used during the day and at night?

Both Shiseido and SK-II offer a range of products suitable for day and night use. Day creams often provide added sun protection, while night creams focus on nourishing and repairing the skin during sleep. It’s beneficial to incorporate products specifically designed for each time of day to maximize their benefits.

Are Shiseido and SK-II products cruelty-free?

Shiseido and SK-II have made efforts to move towards more sustainable and cruelty-free practices. However, it’s recommended to check individual product labels or the brands’ official websites for their latest stance on animal testing and cruelty-free certifications.

Are Shiseido and SK-II products worth the price?

Shiseido and SK-II are known for their high-quality skincare products, and their prices often reflect the research, development, and premium ingredients used. While they may be considered more expensive compared to some other brands, many users find the investment worthwhile due to the visible results and overall satisfaction with the products.


Considering the substantial price difference, along with Shiseido’s impressive trial results and its popularity (selling one every 8.6 seconds), the choice becomes clear. The Shiseido Ultimune Power Infusing Concentrate has our vote of confidence.

Both Shiseido and SK-II offer exceptional skincare products, and ultimately, the choice between them depends on your personal preferences, budget, and specific skincare needs.